C-Terminal lactamization of peptides
Research output: Contribution to journal › Journal article › peer-review
Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
|Number of pages||4|
|Publication status||Published - 2021|