N-acyliminium intermediates in solid-phase synthesis.

Research output: Contribution to journalReviewResearchpeer-review

N-Acyliminium ions are powerful intermediates in synthetic organic chemistry. Examples of their use are numerous in solution-phase synthesis, but there are unmerited few reports on these highly reactive electrophiles in solid-phase synthesis. The present review covers the literature to date and illustrates the methods used to generate N-acyliminium intermediates on solid support and their further elaboration to a range of pharmacologically interesting peptidomimetics, heterocycles, and other small molecules.

Original languageEnglish
Issue number2
Pages (from-to)242-256
Number of pages15
Publication statusPublished - 2010
Externally publishedYes

ID: 321824844