β-Selective mannosylation with a 4,6-silylene-tethered thiomannosyl donor
Research output: Contribution to journal › Journal article › Research › peer-review
Mannosylations using the new conformationally restricted donor phenyl 2,3-di-O-benzyl-4,6-O-(di-tert-butylsilylene)-1-thio-α-D-mannopyranoside (6) have been found to be β-selective with a variety of activation conditions. The simplest activation conditions were NIS/TfOH, in which case it is proposed that the β-mannoside is formed from β-selective glycosylation of the oxocarbenium ion 25 in a B(2,5) conformation.
|Number of pages||4|
|Publication status||Published - 2014|