Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides
Research output: Contribution to journal › Journal article › Research › peer-review
A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.
|Number of pages||4|
|Publication status||Published - 21 Jun 2007|