Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides

Research output: Contribution to journalJournal articleResearchpeer-review

A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.

Original languageEnglish
JournalOrganic Letters
Issue number13
Pages (from-to)2469-2472
Number of pages4
Publication statusPublished - 21 Jun 2007
Externally publishedYes

ID: 321882730