Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides
Research output: Contribution to journal › Journal article › Research › peer-review
A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.
| Original language | English |
|---|---|
| Journal | Organic Letters |
| Volume | 9 |
| Issue number | 13 |
| Pages (from-to) | 2469-2472 |
| Number of pages | 4 |
| ISSN | 1523-7060 |
| DOIs | |
| Publication status | Published - 21 Jun 2007 |
| Externally published | Yes |
ID: 321882730