Plasmodium falciparum antigenically varies proteins at the surfaces of the infected red blood cell and the merozoite to evade immunity. These are fundamental elements of parasitism. We are exploring the adhesive-invasive repertoires of fresh malaria parasites, to identify parasite ligands interacting with synthetic red bloods cells (sRBC). sRBCs are being generated based on Giant Unilamellar Vheicles (GUVs). An array of glycoreceptors (glycolipid, -peptide or –protein) are inserted in synthetic membrane systems of varying lipid compositions in a step-wise, complementary manner. sRBC with synthetic glycocalyx components are made for identification of host receptor employed by the parasite. The interactions of differently functionalized sRBCs with clonal merozoites and infected RBC are studied by fluorescence microscopy among other techniques. By combining biological, analytical and synthetic approaches, the goal is to identify molecular parasite adhesion-invasion events used by the parasite to bind to and penetrate the RBC.