Activities at the Center for Evolutionary Chemical Biology

The CECB research group combine technology and research across many scientific disciplines within a combinatorial chemistry platform. The structure of CECB provides technology for the study of complex mechanisms in molecular recognition and biochemical processing from a chemical point of view. The research at CECB aim at understanding molecular recognition, signalling and processing. Typical topics are GPCR-signalling, enzyme and catalyst processing, molecular recognition for controlling cell behaviour. The research at CECB is therefore at the interface between chemistry, biology and material sciences.

 CECB has developed a range of platform technologies to facilitate the study of recognition, processing and signalling. On-bead assays performed on custom made biocompatible PEG-resins include solid phase FRET protease substrate assays, a cells-on-bead assay for investigation of GPCR-activation, a molecular adhesion assay. Combinatorial chemistry is facilitated by optical bead encoding technology, fluorescence activated bead sorting and super high resolution mass spectrometry.

Read more about the different research topics:

• Cellular Control
• Click chemistries
• Combinatorial chemistries
• Encoding
• GPCR's
• Membranes and materials
• Molecular recognition
• Organozymes
• Peptide chemistry
• Polymers and resins
• Protein function
• Proteolysis