Pedersen Laboratory
Organic synthesis is the red thread in all our projects and our research is based on experimental work. We are interested in understanding the chemistry and studying reaction mechanisms in order to optimize reaction conditions and improve selectivity is in common for many projects. With a profound understanding and a pratical “know how” we develop new methodologies for the synthesis of biological relevant complex natural products and degradation of biomass to simple value-added compounds.
Total Synthesis of glycoconjugates from bacteria has been a main interest for the past years, where we have succeeded to synthesize lipoteichoic acids from S. pneumoniae and C. difficile as well as derivatives thereof. Besides the amazing challenge in synthesizing these very complex amphiphilic molecules an additional goal is to elucidate the biological functions of microbial carbohydrates. We are working close with biologists, immunologists and MD’s to understand the biological role of these molecules.
Carbohydrate chemistry: With the extensive use of carbohydrates in the total syntheses and biomass conversion we have a natural interest in understanding these fascinating molecules. Especially stereoselective synthesis of mixed acetals such as in glycosylations is the target for our research. Studies of the influence of conformation, protective groups and reaction conditions on reactivity and selectivity is of our continuous interest. Our research has so far led us to develop new areas in carbohydrate chemistry including C-H activation, super armed glycosyl donors and Si-sugars.
Biomass Conversion: With increasing worries about the access to cheap oil and its environmental consequences, conversion of waste biomass has gained increased attention. We are particular interested in finding methods to convert carbohydrate based biomass into platform chemicals and biofuel. We use our knowledge from carbohydrate chemistry to study ways to exploit these resources in new and more effective ways.
CURRENT POSITION
2013- Associate professor in organic chemistry – University of Copenhagen
PREVIOUS PROFESSIONAL APPOINTMENTS
2013-2013 Adjunct (Assist. Prof.) University of Copenhagen
2009-2013 Senior post doc. – University of Copenhagen, Prof. Mikael Bols
2007-2008 Post doc. – University of Konstanz, Germany, Prof. Richard R. Schmidt
2006 1st February to 1st June: visitor in Prof. David Crich’s group at University of Illinois at Chicago.
2004-2007 Ph. D. student. - Aarhus University, Bioorganic Chemistry Group, Prof. M. Bols
2003 1st February to 1st July Exchange Visitor at Technische Universität Wien.
2003 Projects with Boehringer-Ingelheim Austria and Prof. Peter Gärtner
1997-2008 Kempas Aps / Optiwood Aps: Advisor and chemist.
EDUCATION
2004-2007 Ph.D. student at Department of Chemistry at the University of Aarhus
2002-2004 Enrolled in the master program at Department of Chemistry at the University of Aarhus
1999-2002 Bachelor student at Department of Chemistry at University of Aarhus.
RESEARCH INTERESTS
Carbohydrate chemistry: Mechanistic studies, new methods and natural product synthesis.
Biomass conversion: Developing new methods for catalytic transformation of biomass.
Carbon-silicon chemistry: Methods for introducing Si into the C-framework of. e.g. carbohydrates.
ADWARDS/GRANTS
- China Association for Instrumental Analysis (CAIA): Second Class, The first accomplisher. Number of the certification:2017-2-008 (2017)
- Chinese Academy of Sciences (CAS): Awarded professorship under the CAS President’s International Fellowship Initiative (PIFI) (2015)
- Shanxi Province: Invited foreign technology and management talent (2015)
- The Villum Foundation for the project: Methods for incorporation of silicon in natural products – stereoelectronic and conformational effects in carbohydrates (2015)
- Roche Continents (2008)
- Danish Research Council for the project: Synthesis of Streptococcus pneumonia Lipoteichoic acid type IV (2007).
BOARDS, COMMISIONS and APPOINTMENTS:
- ”Studienævn for Fysik, Kemi og Nanoscience ved SCIENCE fakultet” (Suppleant 2016-).
- Member of the board, The Danish Chemical Society: Organic Chemistry Section (2014-)
- “Arbejdsmiljøudvalg” Department of Chemistry, KU (2014-)
- International coordinator at Department of Chemistry, KU (2013-16)
- “Kandidatstudienævnet” University of Copenhagen (suppleant) (2010-14)
- “Akademisk Råd” University of Aarhus (2003-2007)
Post Docs
Dr. Niklas Henrik Fischer
Dr. Yuxuan Hou
PhD Students
Natasha Videcrantz Faurschou; nvf@chem.ku.dk
Asger Røikjær Koue; asger@chem.ku.dk
Andreas Ketilsø Dam: akd@chem.ku.dk
Arminas Jurys: aj@chem.ku.dk
Niels Guldager: ng@chem.ku.dk
Tzu-Chun Lin: tcl@chem.ku.dk
Master Students
Amy Rose Lowans
Simon Risegaard
Jens Meisler Nielsen
Jonas Thygesen Larsen
Christine Sofie Haukohl J Schalck
Bachelor / Project students
Halfdan Naundrup Jepsen
Visiting Scholars / Temporary Staff
Victor Friis
Alicja Bałuta
Alumni
Monya Harouel (Project 2012)
Maxime Douarre (Project 2013)
Valentin Rault (Project 2013 / 2016)
Camille Favre (Project 2013)
Guillaume Fanchon (Project 2013)
Elodie Perennes (Project 2014)
Maxime Pulcini (Project 2014)
Pernille S. Bols (Bachelor 2014)
Maria A. Bosi (Project 2015)
Anna G. Lund (Project 2015)
Megha Arya (Visitor 2016)
Eirikur T. Baldursson (Master 2016)
Dasol Hwang (Master 2016)
Hidde Elferink (visitor 2016)
Jun Miyatake Ondozabal (Master 2017 with Haldor Topsøe A/S)
Arminas Jurys (Visitor 2017)
Ignacio Álvarez (Master 2018)
Markus Häner (Visitor 2017-2018)
Muhan Zhao (Visitor 2017-2018)
Bolette Stougaard (Master 2018)
Christian Hammelev (Master 2018)
Julie M. Korsmeyer (Visitor 2018)
Martin Jæger Pedersen (PD 2016-2018)
Daniel Raydan (Master 2018-2019)
Jaime Moyano Villameriel (Master 2018-2019)
Simone Hilt Bartholin (Bachelor 2019)
Thomas Olsen (Bachelor 2019)
Nikolaj Agertoft Lundquist (Bachelor 2019)
Patricja Mala (visiting PhD student 2018/2019)
Kitt E. Østerlid (master student 2019-2020)
Allesandro Pinna (Ph.D. student 2020)
Nikolai B. Akselvoll (bachelor student 2020)
Benedicte Rønne Kristensen (bachelor 2020)
Cecilie Høgfeldt Jessen (bachelor 2020)
Emilie Lundquist Madsen (Project 2020)
Marius Haugstad (Project)
Josephine Fisker (Bachelor 2021)
Søren Peder Christensen (Project)
Thomas Holmstrøm (PhD 2021)
Michael Martin Nielsen (PhD 2021)
Frederik Bjerre (MSc 2021)
Thomas Olsen (MSc 2021)
Nikolaj Agertoft Lundquist (MSc 2021)
Yang Liang (杨 亮) (PhD 2022)
Nienke Julie Dekker (MSc 2022)
Morten Lang Zimmermann (MSc 2022)
Benedicte Rønne Kristensen (MSc 2022)
Andreas Ketils Dam (Bachelor 2022)
Khalid Ileye (Bachelor 2022)
Amy Rose Lowans (Project 2023)
Christine Sofie Haukohl J Schalck (Bachelor 2023)
Jonas Thygesen Larsen (Bachelor 2023)
Jesper Lund Christensen (Bachelor 2023)
Simon Risegaard (Bachelor 2023)
Oliver Blomquist (Bachelor 2023)
Neeraja C. Sajeev (Master 2023)
Vojtech Kunz (Master 2023)
Dr. Xifu Liang (PD 2023)
Dr. Martin Jæger Pedersen (PD 2020-23)
Catalina L. Bigalke (MSc 2024)
Nikolai Bjørn Akselvoll (MSc 2024)
Daniel M. Feldballe (Bachelor 2024)
Anton K. Lawerentz (Bachelor 2024)
Sofie I. H. Skov (Bachelor 2024)
Lærke B. Bødtcher (Bachelor 2024)
Lecturing in applied spectroscopy, sustainable and organic chemistry.
Responsible for the courses:
• “Organisk kemi i naturvidenskab” (15 ECTS)
• “Carbohydrate chemistry” (7.5 ECTS; Ph.D. course)
- “Ring system-based conformational switches and their applications in sensing and liposomal drug delivery” H. Su, C.M. Pedersen SYNTHESIS 2022 (accepted)
- “Vessel effects in organic chemical reactions; a century-old, overlooked phenomenon” M.M. Nielsen, M. Pedersen* Chem. Sci. 2022, 13, 6181-6196
- “Catalytic conversion of d-glucose into lactic acid with Ba(OH)2 as a base catalyst:mechanistic insight by NMR techniques” Y. Zhao, R. Liu, M. Pedersen, Z. Zhang, Z. Guo, H. Chang, Y. Qiao, Y. Wang Mol. Liquids 2022, accepted
- “NMR Diffusion Analysis of Catalytic Conversion Mixtures from Lignocellulose Biomass Using PSYCHE-iDOSY” Q. Zhao, M Pedersen, J. Wang; R. Liu, Y. Zhang, X. Yan, Z. Zhang, X. Hou, Y. Wang Green Energy & Enviroment 2022 (in press, online)
- “Lupeol and pristimerin do not inhibit activation of the human sperm CatSper Ca(2+)-channel” A. Rehfeld, M. Pedersen F1000Research 2022 (accepted - online)
- “Slow glycosylations: Activation of trichloroacetimidates under mild conditions using lithium salts and the role of counterions” N. Korber, M. Pedersen* Carbohydr. Res. 2022, (On-line)
- “Stereoselective O-Glycosylations by Pyrylium Salt Organocatalysis” M.M. Nielsen, T. Holmstrøm, M. Pedersen* Angew. Chem. Int. Ed. 2022 (Accepted – Hot Paper)
- “Silylated Sugars – Synthesis and Properties” M. Bols, T.G. Frihed, M.J. Pedersen, M. Pedersen* SYNLETT 2022, 33, 415-428
- “Interactions between PAMAM-NH2 and 6-mercaptopurine: qualitative and quantitative NMR studies” Asian J. 2021, 16, 3658-3663
- “Self-Promoted Glycosylation for the Synthesis of β-N-Glycosyl Sulfonyl Amides” P. Mala, M. Pedersen* Eur. J. Org. Chem. 2021, 5685-5689
- “Protecting Carbohydrates with Ethers, Acetals and Orthoesters under Basic Conditions” L. Yang, M. Pedersen* Org. Biol. Chem. 2021, 19, 7598-7601
- “Characterization of the acidity and basicity of green solvents by NMR techniques” K. Shi, M. Pedersen, H. Chang, J. Shi, Y. Wang, Y. Qiao Mag. Res. Lett. 2021 (https://doi.org/10.1016/j.mrl.2021.100001)
- "Self-Promoted Stereoselective Glycosylations – Past, Present, Future" N.V. Faurschou,M. Pedersen* The Chem. Rec. , 2021, 21, 3063-3075
- “d-Glucose Isomerization with PAMAM Dendrimers as Environmentally Friendly Catalysts” Z. Guo, M. Pedersen, P. Wang, M. Ma, Y. Zhao, Y. Qiao, Y. Wang J. Agric. Food Chem. 2021, 69, 17, 5105-5112
- “Utilizing 3D DOSY NMR in the characterization of organic compounds in coal chemical wastewater” H. Ma, M. Pedersen, Q. Zhao, S. Jia, B. Yuan, X. Hou, Y. Wang Magn. Reson. Lett. 2021 (https://doi.org/10.1016/j.mrl.2021.100021)
- "Pure shift NMR: Application of 1D PSYCHE and 1D TOCSY-PSYCHE Techniques for Directly Analyzing the Mixtures from Biomass-derived Platform Compound Hydrogenation/hydrogenolysis" Q. Zhao, H: Ma, M. Pedersen, M. Dou, Y. Qiao, X. Hou, Y. Qi, Y. Wang ACS Sus. Chem. Ing. 2021 9, 2456-2464
- “Reactivity, Selectivity and Synthesis of 4-C-Silylated Glycosyl Donors and 4-Deoxy Analogues” M.J. Pedersen, M. Pedersen* Angew. Chem. Int. Ed. 2021 60 2689-2693
- “Carbohydrate Derived Metal Chelator-Triggered Lipids for Liposomal Drug Delivery” T. Holmstrøm, M. G. Malle, S. Wu, K.J. Jensen, N.S. Hatzakis, M. Pedersen* Chem. Eur. J. 2021, 27, 6017-6922 (in-side cover)
- "Easy access to a carbohydrate-based template for stimuli-responsive surfactants" T. Holmstrøm, D Raydan, M. Pedersen* Beilstein J. Org. Chem. 2020 16, 2788-2794
- “Conformational lock of glycosyl donors using cyclic carbamates.” J.M. Villameriel, M. Pedersen* Eur. JOC 2020, 41, 6459-6467
- “Synthesis and Glycosylation Properties of C6-silylated Ido- and Gluco-pyranosyl donors” I. Álvarez, M. Pedersen* Eur JOC, 2020, 4621-4634
- “Enzyme Catalyzed Regioselective Acetylation of Functionalized Glycosides” T. Holmstrøm, M. Pedersen* Eur. JOC 2020, 4612-4615
- "Chemoselectivity in Self-Promoted Glycosylation: N- versus O-Glycosylation." VIP paper Pinna, C. M. Pedersen* Eur. JOC 2020, 3914-3917
- “Ternary deep eutectic solvents catalyzed d-glucosamine self-condensation to
deoxyfructosazine: NMR study” P. Liu, C.M. Pedersen, J. Zhang, R. Liu, Z. Zhang, X. Hou, Y. Wang Green Energy & Environment, 2020, https://doi.org/10.1016/j.gee.2020.04.010.
- “Catalytic and Atom Economic Glycosylation using Glycosyl Formates and Cheap Metal Salts.” L. Yang, C.H. Hammelev, M. Pedersen* CHEMSUSCHEM 2020, 13, 3166-3171
- “Scalable Synthesis of Hydroxymethyl alkylfuranoates as Stable 2,5-Furandicarboxylic acid Precursors” M.J. Pedersen, A. Jurys, M. Pedersen* Green Chem. 2020 22, 2399-2402
- “Mechanistic study on the conversion of d-fructose into deoxyfructosazine: Insights from NMR and DFT study” L. Jia, Y. Qiao, M. Pedersen, S. Jia, H. Ma, Z. Zhang, Y. Wang, X. Hou Chem. Eng. Sci. 2020, 214, 115444
- “Development and characterisation of mouse monoclonal antibodies specific for Clostridiodes (Clostridium) difficile lipoteichoic acid” C. Cairns, H. van Faassen, F. St. Michael, A. Aubry, K. Henry , M. Rossotti, S. Logan, G. Hussack, N. Gisch, W. Hogendorf, Pedersen, A. Cox ACS Chemical Biology 2020,15, 1050–1058
- “Vessel Effect in C–F Bond Activation Prompts Revised Mechanism and Reveals an Autocatalytic Glycosylation” M.M. Nielsen Qiao Y. Wang C.M. Pedersen* Eur. J. Org. Chem. 2020, 140-144
- “a-Selective Glycosylations using Glycosyl N-(ortho-Methoxyphenyl)trifluoroacetimidates” K. Kowalska, M. Pedersen* Org. Biol. Chem. 2020, 18, 1918-1925
- “Palladium(0)-Catalyzed Rearrangement of Allylic Esters” B.M. Jessen, J.M. Ondozabal, M. Pedersen, A. Sølvhøj, E. Taarning, R. Madsen Chem. Select 2020, 5, 2559-2563
- “Conformationally Switchable Glycosyl Donors” T. Holmstrøm, M. Pedersen* J. Org. Chem. 2019, 84, 13242-13251
- “Self-promoted and stereospecific formation of N-glycosides” M. M. Nielsen, P. Mala, E. Baldursson, M. Pedersen* Chem. Sci. 2019, 10, 5299-5307
- “NMR analysis of the Fischer-Tropsch process water: combination of 1D selective gradient TOCSY, 2D DOSY and qNMR” H. Ma, M. Pedersen, Q. Zhao, Z. Lyu, H. Chang, Y. Qiao, X. Hou, Y. Wang Anal. Chim. Acta 2019, 1066, 21-27
- “Interaction between environmental contaminant PFOA and PAMAM in water: 19F and 1H NMR studies” C. Ning, H. Ma, M. Pedersen, H. Chang, Y. Wang, Y. Qiao Mol. Liq. 2019, 283, 45-50
- “Synthesis of a-d-GalpN3-(1-3)-d-GalpN3: a- and 3-O-Selectivity Using 3,4-Diol Acceptors” E. Glibstrup, M. Pedersen* Beilstein J. Org. Chem. 2018, 14, 2805-2811
- “Conformational distortion using a molecular lever: Galactoside derivatives” M. Häner, C. H. Hammelev, M. Pedersen* Eur. J. Org. Chem. 2018, 40, 5532-5537
- “NMR studies of the tautomer distributions of D-fructose in lower alcohols/DMSO-d6” K. Shi, M. Pedersen, Z. Guo, Y. Li, H. Zheng,Y. Qiao, Y. Wang J. Mol. Liq. 2018 (DOI: 10.1016/j.molliq.2018.09.067)
- “Catalytic Glycosylation in Oligosaccharide Synthesis” M.M. Nielsen andM. Pedersen* Chem. Rev. 2018, 118, 8285-8358
- “DESs: green solvents and catalysts for the preparation of pyrazine derivatives by self-condensation of D-glucosamine” Wu, M.; Ma, H.; Ma, Z.; Jin, Y.; Chen, C.; Guo, X.; Qiao, Y.; Pedersen, C.; Hou, X.; Wang, Y. ACS Sus. Chem. Eng. 2018, 6, 9434-9441
- “Ca2+-Assisted DOSYNMR: An Unexpected Tool for Anomeric Identification for d‑Glucopyranose” C. Ning, W. Ge, Z. Lyu, D. Luo, K. Shi, M. Pedersen, M.M. Nielsen, Y. Qiao, Y. Wang ChemistrySelect 2018, 3, 3943-3947
- “Isomeric distribution of monosaccharides in deep eutectic solvents: NMR study” M. Wu, W. Zhou, M. Pedersen, H. Ma, Y. Qiao, X. Guo, X. Hou, Y. Wang J. Mol. Liq. 2018, 255, 244-249
- “Combination of DOSY and 1D selective gradient TOCSY: versatile NMR tools for identify the mixtures from glycerol hydrogenolysis reaction” C. Li, J. Shan, X. Yan, D. Xiang, F, Yue, Y.-X. Wang, Z. Lyu, M. Pedersen, Y. Qiao FPT 2018, 171, 117-123
- “NMR Studies of Stock Process Water and Reaction Pathways in Hydrothermal Carbonization of Furfural Residue” Y. Feng, M. Pedersen, X. Yan, Y. Liu, D. Xiang, C. Ning, Y. Wang, Y. Qiao Green Energy & Environment, 2018, 3, 163-171
- “Graphene oxide: a novel acid catalyst for the synthesis of 2,5-dimethyl-N-phenyl pyrrole by the Paal-Knorr condensation” C.-Y. Chen, X.-Y. Guo, G.-Q. Lu, M. Pedersen, Y. Qiao, W.-L. Hou Y.-X. Wang New Carbon Mat. 2017, 32, 160-167
- “Valorization of Furfural Residue by Hydrothermal Carbonization: Processing Optimization, Chemical and Structural Characterization” F. Yue, J. Zhang, M. Pedersen, Y. Wang, T. Zhao, P. Wang, Y. Liu, G. Qian, Y. Qiao ChemistrySelect 2017, 2, 583-590
- “Product Distribution Control for Glucosamine Condensation: NMR Investigation Substantiated by Density-Functional Calculations” L. Jia, Z. Zhang, Y. Qiao, M. Pedersen, H. Ge, Z. Wei, T. Deng, J. Ren, X. Liu, Y.-X. Wang, X. Hou, Ind. Eng. Chem. Res. 2017, 56, 2925-2934
- “On the nature of electronic effect of multiple hydroxyl groups in the 6-membered ring – the effects are additive but steric hindrance play a role too” M. Pedersen*, M. Bols, Org. Biomol. Chem. 2017, 15, 1154-1173
- “Glycosyl Fluorides as Intermediates in the BF3∙OEt2 Promoted Glycosylation with Trichloroacetimidates” M.M. Nielsen, B.A. Stougaard, M. Bols, E. Glibstrup, M. Pedersen* Eur. JOC 2017, 1281-1284
- “Catalytic stereospecific O-glycosylation” K. Kowalska, M. Pedersen* Chem. Commun. 2017, 53, 2040-2043
- “Silyl protective groups influencing reactivity and selectivity in glycosylations” M. Bols, M. Pedersen* Beilstein JOC 2017, 13, 93-105
- “Rhamnosylation: The solvent is the Solution” H. Elferink, M. Pedersen* Eur. J. Org. Chem.2017, 53-59
- “Mechanism of the Self-condensation of GlcNH2: Insights from in Situ NMR Spectroscopy and DFT Study” L. Jia, X. Liu, Y. Qiao, M. Pedersen, Z. Zhang, H. Ge, Z. Wei, Y. Chen, X. Wen, X. Hou, Y.X. Wang Applied Catalysis B: Environmental 2017, 202, 420-429
- “Conformationally superarmed S-ethyl glycosyl donors as effective building blocks for chemoselective oligosaccharide synthesis in one pot” M. Bandara, P. Yasomanee, N.P. Rath, C.M. Pedersen,* M. Bols,* A.V. Demchenko* Org. Biomol. Chem. 2017, 15, 559-563
- "NMR insights into the unexpected interaction of SnCl₄ with D-glucosamine and its effect on 5-HMF preparation in ZnCl₂ molten salt hydrate medium" C. Chen, W. Ge, L. Jia, M. Pedersen, Y. Qiao, S. Jia, X. Guo, Y. Wang, X. Hou ChemistrySelect 2016, 1, 6540-6545
- “Scalable Synthesis of Anomerically Pure Orthogonal Protected GlcN3 and GalN3 from D-Glucosamine” E. Glibstrup, M. Pedersen* Org. Lett. 2016, 18, 4424-4427
- “Glycosylation Intermediates Studied by Low Temperature 1H- and 19F-DOSY NMR: New Insight into the Activation of Trichloroacetimidates.” Y. Qiao, W. Ge, L. Jia, Hou, Y. Wang, C.M. Pedersen* Chem. Commun. 2016, 52, 11418-11421
- “Mechanism study of Cr(III) immobilization in the process of Cr(VI) removal by Huolinhe lignite” T.-T. Zhao, W.-Z. Ge, F. Yue, Y.-X.Wang, M. Pedersen, F.-G. Zeng, Y. Qiao Fuel Processing Technology 2016, 152, 375-380
- "NMR study of the hydrolysis and dehydration of inulin in water: Comparison of the catalytic effect of Lewis acid SnCl4 and Brønsted acid HCl" Y. Qiao, M. Pedersen, D. Huang, W. Ge, M. Wu, C. Chen, S. Jia, Y.-X. Wang, W. Hou ACS Sustainable Chemistry & Engineering 2016, 4, 3327-3333
- “C-H Functionalization of Carbohydrates” T.G. Frihed, M. Bols, M. Pedersen* Eur. J. Org. Chem. 2016, 16, 2740-2756
- “DOSY NMR: A Versatile Analytical Chromatographic Tool for Lignocellulosic Biomass Conversion” W. Ge, J.H. Zhang, M. Pedersen, T. Zhao, F. Yue, C. Chen, P. Wang, Y. Wang, Y. Qiao ACS Sustainable Chem. Eng., 2016, 4, 1193-1200
- “Super Arming of a Glycosyl Donor Using a Molecular Lever” J. I. Olsen, K. Kowalska, M. Pedersen* and M. Bols* Tetrahedron Lett. 2016, 57, 35-38
- “Pyrolysis of chitin biomass: TG-MS analysis and solid char residue characterization” Y. Qiao, S. Chen, Y. Liu, H. Sun, S. Jia, J. Shi, M. Pedersen, Y. Wang, X. Hou Carbohydr. Polymers 2015, 130, 163-170
- “Glucosamine condensation catalysed by 1-ethyl-3-methylimidazolium acetate: mechanistic insight from NMR spectroscopy” Jia, C.M. Pedersen, Y. Qiao, T. Deng, P. Zuo, W. Ge, Z. Qin, X. Hou, Y. Wang Physical Chemistry Chemical Physics 2015, 17, 23173-23182
- “β-Mannosylation with 4,6-benzylidene protected mannosyl donors without preactivation” M. Heuckendorff, P. S. Bols, C. Barry, T. G. Frihed, M. Pedersen*, M. Bols* Chem. Commun. 2015, 51, 13283-13285
- “A fluorescence study of isofagomine protonation in β-glucosidase” E. Lindback, B.W. Laursen, J.C.N. Poulsen, K. Kilså, M. Pedersen, M. Bols Org. Biomol. Chem. 2015, 13, 6562-6566
- “Synthesis of l-Hexoses” T. Frihed, Bols, M. Pedersen* Chem. Rev. 2015, 115, 3615-3676
- “Mechanisms of Glycosylation Reactions Studied by Low Temperature NMR” T. Frihed, M. Bols, M. Pedersen* Chem. Rev. 2015, 115, 4963-5013
- ”Exploring the relationship between conformation and pKa: Can a pKa value be used to determine the conformational equilibrium?” J. I. Olsen, M. Pedersen*, M. Bols Org. Biomol. Chem. 2015, 13, 3116-3121
- “In situ NMR spectroscopy: Inulin biomass conversion in ZnCl2 molten salt hydrate medium—SnCl4 addition controls product distribution” Y. Wang, M. Pedersen, Y. Qiao, T. Deng, J. Shi, X. Hou Carbohydr. Polymers 2015, 115, 439-443
- “NMR Insights on the properties of ZnCl2 Molten Salt Hydrate Medium through its Interaction with SnCl4 and Fructose” Y. Qiao, M. Pedersen, Y. Wang, X. Hou ACS Sus. Chem. & Eng. 2014, 2, 2576-2581
- ”Synthesis of All Eight Stereoisomeric 6-Deoxy-L-Hexopyranosyl Donors – Trends in Using Stereoselective Reductions or Mitsunobu Epimerizations” T. G. Frihed, C.M. Pedersen*, Bols* Eur. JOC 2014, 35, 7924
- ”Synthesis of All Eight L-Glycopyranosyl Donors Using C-H Activation” T.G. Frihed, M. Pedersen*, M. Bols* Angew. Chem. Int. Ed. 2014, 53, 13889
- “Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid” E. Stermann, M. Lacroix, E. Gout, E. Lafly, M. Pedersen, L. Martin, A. Amoroso, R.R. Schmidt, U. Zähringer, C. Gaboriaud, A.M. Di Guilmi, N.M. Thielens J. Immunol. 2014, 193, 5699-5708
- “Total Synthesis of Five Lipoteichoic acids of Clostridium difficile” W.F.J. Hogendorf, N. Gisch, D. Schwudke, H. Heine, M. Bols, M. Pedersen* Chem. Eur. J. 2014, 20, 13511 – 13516
- “Cyclodextrin-based artificial oxidases with high rate accelerations and selectivity” Y. Zhou, E.A. Lindbäck, M. Pedersen, M. Bols Tetrahedron Lett. 2014, 55, 2304-2307
- “β-Selective mannosylation with a 4, 6-silylene-tethered thiomannosyl donor” M. Heuckendorff, M. Pedersen*, M. Bols* Org. Lett. 2014, 16, 1116-1119
- “Synthesis and thermotropic phase behavior of four glycoglycerolipids” W.F.J. Hogendorf, V. Jagalski, T.G. Pomorski, M. Bols, M. Cárdenas, M. Pedersen* Molecules 2013, 18, 13546-13573
- “Superarming of Glycosyl Donors by Combined Neighboring and Conformational Effects” M. Heuckendorff, H.D. Premathilake, P. Pornsuriyasak, A.Ø. Madsen, M. Pedersen,* M. Bols, A.V. Demchenko Org. Lett. 2013, 15, 4904-4907
- “Conformationally armed 3, 6-tethered glycosyl donors: synthesis, conformation, reactivity, and selectivity” M. Heuckendorff, M. Pedersen,* M. Bols* J. Org. Chem. 2013, 78, 7234-7248
- “Direct conversion of chitin biomass to 5-hydroxymethylfurfural in concentrated ZnCl2 aqueous solution” Y. Wang, M. Pedersen, T. Deng, Y. Qiao, X. Hou Bioresour. Technol. 2013, 143, 384-390
- “Diethyl silane” T. G. Frihed, M. Bols, M. Pedersen* e-EROS Encyclopedia of Reagents for Organic Synthesis (Online, 2013)
- “Enzyme inhibition by iminosugars: Analysis and insight into the glycosidase–iminosugar dependency of pH” Ó. López, F.L. Qing, M. Pedersen, M. Bols Bio. Org. Med. Chem. 2013 (Online)
- “Artificial enzyme activity from cyclodextrins with cyanohydrins on the secondary rim” Y. Zhou, M. Pedersen, M. Bols Tetrahedron Lett. 2013, 54, 2458-2461
- “Influence of O6 in mannosylations using benzylidene protected donors: stereoelectronic or conformational effects?” T.G. Frihed, M.T.C. Walvoort, J.D.C. Codée, G.A. van der Marel, M. Bols, M. Pedersen* J. Org. Chem. 2013, 78, 2191-2205
- “Total synthesis of biologically active lipoteichoic acids” M. Pedersen*, M. Bols, Y. Qiao ARKIVOC 2013, 2, 249-275
- ”Easy Access to L‐Mannosides and L‐Galactosides by Using C-H Activation of the Corresponding 6‐Deoxysugars” T.G. Frihed, M. Heuckendorff, M. Pedersen*, M. Bols* Angew. Chem. Int. Ed. 2012, 51, 12285-12288
- “Synthesis of Tin‐Containing Cyclodextrins as Potential Enzyme Models” Y. Zhou, L. Marinescu, M. Pedersen, M. Bols Eur. J. Org. Chem. 2012, 32, 6383-6389
- “Molecular and functional characterization of the interaction of L-ficolin with Streptococcus pneumoniae” E. Stermann, M. Lacroix, E. Gout, E. Laffly, M. Pedersen, R. R. Schmidt, T. Vernet, C. Gaboriaud, A.-M. Di Guilmi, N.M. Thielens Immunobiology 2012, 217, 1188-1189
- “Synthesis of cyclodextrins with carboxylic acids at the secondary rim and an evaluation of their properties as chemzymes for glycoside hydrolysis” Y. Zhou, E. Lindbaeck, L.G. Marinecsu, M. Pedersen, M. Bols Eur. J. Org. Chem. 2012, 27, 4063-4070
- “Artificial enzymes based on cyclodextrin with phenol as the catalytic group” E. Lindbäck, Y. Zhou, M. Pedersen*, M. Bols* Tetrahedron Letters 2012, 53, 5023-5026
- ”Two diastereomeric artificial enzymes with different catalytic activity” E. Lindbäck, M. Pedersen, M. Bols Eur. J. Org. Chem. 2012, 27, 5366-5372
- “Rhamnosylation: diastereoselectivity of conformationally armed donors” M. Heuckendorff, M. Pedersen*, M. Bols J. Org. Chem. 2012, 77, 5559-5568
- “A uronic acid analogue of isofagomine lactam as a nanomolar glucuronidase inhibitor” E. Lindback, Y. Zhou, Ó. López, J. G. Fernández-Bolaños, M. Pedersen, M. Bols Tetrahedron Letters 2012, 53, 2045-2047
- ”Conversion of d-glucose into 5-hydroxymethylfurfural (HMF) using zeolite in [Bmim]Cl or tetrabutylammonium chloride (TBAC)/CrCl2” H. Jadhav, E. Taarning, M. Pedersen, M. Bols Tetrahedron Letters 2012, 53, 983-985
- ”Synthesis of the repeating unit of the lipoteichoic acid of Streptococcus pneumoniae” M. Pedersen*, I. Figueroa-Perez, A.J. Ulmer, U. Zähringer R.R. Schmidt Tetrahedron 2012, 68, 1052-1061
- “The influence of neighboring group participation on the hydrolysis of 2-O-substituted methyl glucopyranosides” M. Heuckendorff, M. Pedersen*, M. Bols Organic Letters 2011, 13, 5956-5959
- “3‐Deoxy‐glucosone is an Intermediate in the Formation of Furfurals from D‐” H. Jadhav, C.M. Pedersen, T. Sølling, M. Bols ChemSusChem 2011, 4, 1049-1051
- “A study of anhydrocelluloses–Is a cellulose structure with residues in a 1 C 4-conformation more prone to hydrolysis?” V. Jadhav, M. Pedersen*, M. Bols Org. Biol. Chem. 2011, 9, 7525-7534
- “Recognition of Peptides by Cyclodextrin Trimers” H.S. Christensen, B.W. Sigurskjold, T.G. Frihed, L. Marinescu, M. Pedersen, M. Bols Eur. J. Org. Chem. 2011, 27, 5279-5290
- “Quantifying the Electronic Effects of Carbohydrate Hydroxy Groups by Using Aminosugar Models” M. Pedersen*, J. I. Olsen, A. Brka, M. Bols* Chem. Eur. J. 2011, 17, 7080-7086
- ”Chemical synthesis of bacterial lipoteichoic acids: an insight on its biological significance” U. Zähringer, M. Pedersen, Y. Qiao, R.R. Schmidt Org. Biol. Chem. 2011, 9, 2040-2052
- “Glycosyl donors in “unusual” conformations–influence on reactivity and selectivity” M.Pedersen, L. G. Marinescu, M. Bols Compt. Rend. Chim. 2011, 14, 17-43
- “Synthesis of 5‐Bromomethylfurfural from Cellulose as a Potential Intermediate for Biofuel” N. Kumar, J. Olsen, M. Pedersen, M. Bols Eur. J. Org Chem.2011, 7, 1266-1270
- “Quantifying electronic effects of common carbohydrate protecting groups in a piperidine model system” M. Heuckendorff, M. Pedersen*, M. Bols Chem. Eur. J. 2010, 16, 13982-94 (VIP paper)
- “The Grignard Reaction of Cyclodextrin‐6‐aldehydes Revisited: A Study of the Stereoselectivity Upon Addition of Organometallic Reagents to Aldehydes and Ketones” E. Lindback, Y. Zhou, L.G. Marinescu, M. Pedersen, M. Bols Eur. J. Org. Chem. 2010, 20, 3883-96
- “Synthesis of the core structure of the lipoteichoic acid of Streptococcus pneumoniae” M. Pedersen, I. Figueroa-Perez, J. Boruwa, B. Lindner, A.J. Ulmer, U. Zähringer R.R. Schmidt Chem. Eur. J. 2010, 16, 12627-41
- “Total synthesis of lipoteichoic acid of Streptococcus pneumoniae” M. Pedersen, I. Figueroa-Perez, B. Lindner, A.J. Ulmer, U. Zähringer R.R. Schmidt Angew. Chem.Int. Ed. 2010 49, 2585-90 (“Hot Paper”)
- “An extended study of dimeric phenyl tropanes” S. Nielsen, M. Pedersen, S.G. Hansen, M.D. Petersen, S. Sinning, O. Wiborg, H.H. Jensen, M. Bols Bioorganic & Medicinal Chemistry, 2009, 17, 4900-9
- “Conformationally armed glycosyl donors: reactivity quantification, new donors and one pot reactions” M. Pedersen, L.G. Marinescu, M. Bols Chem. Commun. 2008, 2465-2467
- “Going to extremes:“super” armed glycosyl donors in glycosylation chemistry” H.H. Jensen, M. Pedersen, M. Bols, Chem. Eur. J., 2007, 13, 7576-7582
- ““Super armed” glycosyl donors: conformational arming of thioglycosides by silylation” M. Pedersen, L.-U. Nordstrøm, M. Bols, J. Am. Chem. Soc. 2007,129, 9222-9235
- “On the use of 3, 5-O-benzylidene and 3, 5-O-(di-tert-butylsilylene)-2-O-benzylarabinothiofuranosides and their sulfoxides as glycosyl donors for the synthesis of β-arabinofuranosides: importance of the activation method” D. Crich, M. Pedersen, A.A. Bowers, Wink, D. J. Org. Chem. 2007, 72, 1553-1565
- “Stereochemical substituent effects: investigation of the cyano, amide and carboxylate group” M. Pedersen, M. Bols Tetrahedron, 2005, 61, 115-122
- ”On the electronic effects of OH groups. Synthesis and investigation of tetrahydroxylated azabicycloheptanes” A. Gregersen, M. Pedersen, H. H. Jensen, M. Bols Org. Biomol. Chem. 2005, 3, 1514-1519
- “Radical substitution with azide: TMSN3–PhI(OAc)2 as a substitute of IN3” M. Pedersen, L.G. Marinescu, M. Bols Org. Biomol. Chem., 2005, 3, 816.
- “Safe radical azidonation using polystyrene supported diazidoiodate (I)” L.G. Marinescu, M. Pedersen, M. Bols Tetrahedron, 2005, 61, 123-127.
Contact
Pedersen Laboratory
Department of Chemistry
Universitetsparken 5
DK-2100 Copenhagen O
Christian Marcus Pedersen
Group leader, Associate Professor
Office: B412
DIR: +45 35 32 01 90
MOB: +45 40 18 55 76