Ultrabright Fluorescent Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices**
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Ultrabright Fluorescent Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices**. / Chen, Junsheng; Fateminia, S. M. Ali; Kacenauskaite, Laura; Baerentsen, Nicolai; Gronfeldt Stenspil, Stine; Bredehoeft, Jona; Martinez, Karen L.; Flood, Amar H.; Laursen, Bo W.
In: Angewandte Chemie International Edition, Vol. 60, No. 17, 19.04.2021, p. 9450-9458.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ultrabright Fluorescent Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices**
AU - Chen, Junsheng
AU - Fateminia, S. M. Ali
AU - Kacenauskaite, Laura
AU - Baerentsen, Nicolai
AU - Gronfeldt Stenspil, Stine
AU - Bredehoeft, Jona
AU - Martinez, Karen L.
AU - Flood, Amar H.
AU - Laursen, Bo W.
PY - 2021/4/19
Y1 - 2021/4/19
N2 - Ultrabright fluorescent nanoparticles (NPs) hold great promise for demanding bioimaging applications. Recently, extremely bright molecular crystals of cationic fluorophores were obtained by hierarchical coassembly with cyanostar anion-receptor complexes. These small-molecule ionic isolation lattices (SMILES) ensure spatial and electronic isolation to prohibit aggregation quenching of dyes. We report a simple, one-step supramolecular approach to formulate SMILES materials into NPs. Rhodamine-based SMILES NPs stabilized by glycol amphiphiles show high fluorescence quantum yield (30 %) and brightness per volume (5000 M-1 cm(-1)/nm(3)) with 400 dye molecules packed into 16-nm particles, corresponding to a particle absorption coefficient of 4x10(7) M-1 cm(-1). UV excitation of the cyanostar component leads to higher brightness (>6000 M-1 cm(-1)/ nm(3)) by energy transfer to rhodamine emitters. Coated NPs stain cells and are thus promising for bioimaging.
AB - Ultrabright fluorescent nanoparticles (NPs) hold great promise for demanding bioimaging applications. Recently, extremely bright molecular crystals of cationic fluorophores were obtained by hierarchical coassembly with cyanostar anion-receptor complexes. These small-molecule ionic isolation lattices (SMILES) ensure spatial and electronic isolation to prohibit aggregation quenching of dyes. We report a simple, one-step supramolecular approach to formulate SMILES materials into NPs. Rhodamine-based SMILES NPs stabilized by glycol amphiphiles show high fluorescence quantum yield (30 %) and brightness per volume (5000 M-1 cm(-1)/nm(3)) with 400 dye molecules packed into 16-nm particles, corresponding to a particle absorption coefficient of 4x10(7) M-1 cm(-1). UV excitation of the cyanostar component leads to higher brightness (>6000 M-1 cm(-1)/ nm(3)) by energy transfer to rhodamine emitters. Coated NPs stain cells and are thus promising for bioimaging.
KW - cell imaging
KW - cyanostar macrocycles
KW - fluorescent dyes
KW - fluorescent nanoparticles
KW - SMILES
U2 - 10.1002/anie.202100950
DO - 10.1002/anie.202100950
M3 - Journal article
C2 - 33577094
VL - 60
SP - 9450
EP - 9458
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 17
ER -
ID: 286626492