Catalysis - Lee Group

This is the Nano-Science Center webpage of the Lee group, which is located at the Department of Chemistry (Organic Chemistry Section, Nanoscience Center) University of Copenhagen, Denmark. We are aiming to develop new catalytic methodologies for organic syntheses using state-of-the-art functionalized materials, contributing to society and scientific communities by providing solutions for current global issues.












34. Extended Pummerer Fragmentation Mediated by Carbon Dioxide and Cyanide
L. Jian, R. R. Kragh, F. S. Kamounah, J.-W. Lee Tetrahedron 2020, under review (invited)

33. CO2-Enabled Cyanohydrin Synthesis and Facile Iterative Homologation Reactions
M. Juhl, A. R. Petersen, J,-W. Lee Chem. Eur. J. 2020, Preprint

32. CO2 (de)Activation in Carboxylation Reactions: A Case Study Using Grignard Reagents and Nucleophilic Bases
J. M. V. Lauridsen, S. Y. Cho, H. Y. Bae, J,-W. Lee Organometallics, 2020, 39, 1652-1657 (invited)

31. Cyanide Mediated Synthesis of Sulfones and Sulfonamides from Vinyl Sulfones
T. Roy, J.-W. Lee, Synlett, 2020, 31, 455-458 (invited for 11th EuCheMS Organic Division Young Investigator Workshop)

30. Palladium-Catalyzed Oxidative Homocoupling of Pyrazole Boronic Esters to Access Versatile Bipyrazoles and the Flexible Metal–Organic Framework Co(4,4′-bipyrazolate)
M. K. Taylor, M. Juhl, G. B. Hadaf, D. Hwang, E. Velasquez, J. Oktawiec, J. B. Lefton, T. Runčevski, J. R. Long, J.-W. Lee, Chem. Commun., 2020, 56, 1195-1198.

29. Mode of Action of Quinoline Antimalarial Drugs in Red Bblood Cells Infected by Plasmodium Falciparum, Revealed in-vivo
S. Kapishnikov, T. Staalsø, Y. Yang, J.-W. Lee, A. J. Perez-Berna, E. Pereiro, Y. Yang, S. Werner, P. Guttmann, L. Leiserowitz, J. Als-Nielsen, Proc. Natl. Acad. Sci. 2019, 116, 22946-22952.

28. Carbon Dioxide-Catalyzed Stereoselective Cyanation Reaction
T. Roy, M. Kim, Y. Yang, S. Kim, G. Kang, X. Ren, A. Kadziola, H.-Y. Lee, M.-H. Baik, J.-W. Lee, ACS Catalysis 2019, 9, 6066-6011 (supplementary cover)

27. Toward Ideal Carbon Dioxide Functionalization
Y. Yang, J.-W. Lee, Chem. Sci. 2019, 10, 3905-3926. (front cover highlight)

26. Aldehyde Carboxylation: A Concise DFT Mechanistic Study and a Hypothetical Role of CO2 in the Origin of Life
M. Juhl, M. J. Kim, H.-Y. Lee, M.-H. Baik, J.-W. Lee, Synlett 2019, 30, 987-996 (Synpact invited)

25. Umpolung Reactivity of Aldehydes toward Carbon Dioxide
M. Juhl, J.-W. Lee​, Angew. Chem. Int. Ed. 2018, 57, 12318-12322.

24. Asymmetric Aminalization via Cation-Binding Catalysis
S. Y. Park, Y. Liu, J. S. Oh, M. Duan, Y. K. Kweon, J.-W. Lee, H. Yan, C. E. Song, Chem. Eur. J. 2018, 24, 1020-1025.​

23. A Microporous Amic Acid Polymer for Enhanced Ammonia Capture
J.-W. Lee, G. Barin, G. W. Peterson, J. Xu, K. A. Colwell, J. R. Long, ACS Appl. Mater. Interfaces 2017, 9, 33504-33510.

22. Asymmetric Cation-Binding Catalysis
M. T. Oliveira, J.-W. Lee, ChemCatChem 2017, 9, 377-384. (back cover highlight)

21. Hydrogen-Bond Promoted Nucleophilic Fluorination: Concept, Mechanism and Applications in Positron Emission Tomography
J.-W. Lee, M. T. Oliveira, H. B. Jang, D. W. Kim, S. Lee, D. Y. Chi, C. E. Song, Chem. Soc. Rev. 2016, 45, 4638-4650. (Inside back cover)

Before Copenhagen

20. Textile Catalysts—An unconventional approach towards heterogeneous catalysis
T. Mayer-Gall, J.-W. Lee, K. Opwis, B. List, J. S. Gutmann, ChemCatChem 2016, DOI: 10.1002/cctc.201501252.

19. Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks
H. Zhao, S. Sen, T. Udayabhaskararao, M. Sawczyk, K. Kucanda, D. Manna, P. K. Kundu, J.-W. Lee, P. Král, R. Klajn, Nature Nanotech. 2016, 11, 82-88.

18. Investigation of Cationic Claisen-type Electrophilic Rearrangements of Amides
​M. Padmanaban, L. C. R. Carvalho, D. Petkova, J.-W. Lee, A. S. Santos, M. M. B. Marques, N. Maulide, Tetrahedron 2015, 71, 5994-6005

17. Parts-per-million Level Loading Organocatalysed Enantioselective Silylation of Alcohols
​S. Y. Park, J.-W. Lee, C. E. Song, Nature Commun. 2015, 6:7512, DOI: 10.1038/ncomms8512 (Highlighted in Synfacts 2015, 11, 0985)

16. Dual-Responsive Nanoparticles that Self-Assemble under the Simultaneous Action of Light and CO2
J.-W. Lee, R. Klajn, Chem. Commun. 2015, 51, 2036-2039

15. Organotextile Catalysis
J.-W. Lee, T. Mayer-Gall, K. Opwis, C. E. Song, J. S. Gutmann, B. List, Science 2013, 341, 1225-1229.
(Highlighted in Nature Chem. 2013, 5, 896-897; C&EN 2013, 9, 5; Synfacts 2013, 9, 1343; Synform 2013, 12, A150)

14. Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters to Aldehydes
H. Y. Bae, J. H. Sim, J.-W. Lee, B. List, C. E. Song, Angew. Chem. Int. Ed. 2013, 52, 12143-12147

13. Bifunctional Organocatalyst for Methanolytic Desymmetrization of Cyclic Anhydrides: Increasing Enantioselectivity by Catalyst Dilution
​H. S. Rho, S. H. Oh, J.-W. Lee, J. Y. Lee, J. Chin, C. E. Song, Chem. Commun. 2008, 1208-1210

12. Deracemization of a-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
J.-W. Lee, B. List, J. Am. Chem. Soc. 2012, 134, 18245-18248

11. Scalable Organocatalytic Asymmetric Strecker Reactions Catalysed by a Chiral Cyanide Generator
H. Yan, J. S. Oh, J.-W. Lee, C. E. Song, Nature Commun. 2012, 3, DOI: 10.1038/ncomms2216

10. Self-association Free Bifunctional Thiourea Organocatalysts: Synthesis of Chiral a-Amino Acids via Dynamic Kinetic Resolution of Racemic Azlactones
​J. S. Oh, J.-W. Lee, T. H. Ryu, J. H. Lee, C. E. Song, Org. Bimol. Chem. 2012, 10, 1052-1055

9. A Chiral-Anion Generator: Application to Catalytic Desilylative Kinetic Resolution of Silyl-Protected Secondary Alcohols
H. Yan, H. B. Jang, J.-W. Lee, H. K. Kim, S. W. Lee, J. W. Yang, C. E. Song, Angew. Chem. Int. Ed. 2010, 49, 8915-8917

8. Toward Understanding the Origin of Positive Effects of Ionic Liquids on Catalysis: Formation of More Reactive Catalysts and Stabilization of Reactive Intermediates and Transition States in Ionic Liquids
J.-W. Lee, J. Y. Shin, Y. S. Chun, H. B. Jang, C. E. Song, S.-g., Lee, Acc. Chem. Res. 2010, 43, 985-994

7. Self Association-Free Dimeric Cinchona Alkaloid Organocatalysts: Unprecedented Catalytic Activity, Enantioselectivity and Catalyst Recyclability in Dynamic Kinetic Resolution of Racemic Azlactones
J.-W. Lee, T. H. Ryu, J. S. Oh, H. Y. Bae, H. B. Jang, C. E. Song, Chem. Commun. 2009, 7224-7226

6. Oligoethylene Glycols as Highly Efficient Mutifunctional Promoters for Nucleophilic-Substitution Reactions
​V. H. Jadhav, S. H. Jang, H.-J. Jeong, S. T. Lim, M.-H. Sohn, J.-Y. Kim, S. Lee, J.-W. Lee, C. E.Song, D. W. Kim, Chem. Eur. J. 2012, 18, 3918-3924

5. A Highly Reactive and Enantioselective Bifunctional Organocatalyst for Methanolytic Desymmetrization of Cyclic Anhydrides: Preventing Catalyst Aggregation
​S. H. Oh, H. S. Rho, J.-W. Lee, J. E. Lee, S. H. Youk, J. Chin, C. E. Song, Angew. Chem. Int. Ed. 2008, 47, 7872-7875

4. Bis-Terminal Hydroxyl Polyethers as All-Purpose, Multifunctional Organic Promoters: A Mechanistic Investigation and Applications
J.-W. Lee, H. Yan, H. B. Jang, H. K. Kim, S.-W. Park, S. Lee, D. Y. Chi, C. E. Song, Angew. Chem. Int. Ed. 2009, 48, 7683-7686

3. Hydrogenation of Arenes by Dual Activation: Reduction of Substrates Ranging from Benzene to C60 Fullerene under Ambient Conditions
R. R. Deshmukh, J.-W. Lee, U. S. Shin, J. Y. Lee, C. E. Song, Angew. Chem. Int. Ed. 2008, 47, 8616-8617.

2. A Polymer-Supported Cinchona-based Bifunctional Sulfonamide Catalyst: a Highly Enantioselective, Recyclable Heterogeneous Organocatalyst
​S. H. Youk, S. H. Oh, H. S. Rho, J. E. Lee, J.-W. Lee, C. E. Song, Chem. Commun. 2009, 2220-2222

1. Activation of Lewis Acid Catalysts in the Presence of an Organic Salt Containing a Non-Coordinating Anion: Its Origin and Application Potential
J. H. Kim, J.-W. Lee, U. S. Shin, J. Y. Lee, S.-g. Lee, C. E. Song, Chem. Commun. 2007, 4683-4685